puzzle picture
368: CASP9 Puzzle 36 Revisited
Status: Closed


2Anthropic Dreams10,68570
3Richard Dawkins Foundation10,61748
4Team Tornado10,51033
5Void Crushers10,49621
6Slovak National Team10,46514
8Natural Abilities10,4165
10Mojo Risin'10,3492
11Go Science10,2961
12L'Alliance Francophone10,2521
13Russian team10,2121
15Another Hour Another Point10,1061
17Canadian Universities9,7101
18Crunching Family9,6361
21Rice Biochemistry8,4291

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Joined: 08/11/2010
initial scores for the 9 reserve templates

hat tip to NinjaGreg for clarifying what we're supposed to be doing.

I believe the idea is to take the 9 starting positions mentioned above and try to improve on them, or find a different folding theme. The 9 positions are the initial game start plus the 8 positions obtained by going into design mode, then "Show Alignment" then applying "Thread from Active Template" (the happy face) to each of the Reserve Templates (scroll with the <-- arrows --> near the bottom. Apologies for veterans to whom this is obvious.

Here's my results after initial shake / wiggle / shake for the 9 (your mileage may vary). Would like to save one or two folders from wasting the hour I just did ;-)

0 (initial game position) -- 8446
1 -- 9660; 2 -- 9598; 3 -- 9659; 4 -- 9642
5 -- 9675; 6 -- 9661; 7 -- 9623; 8 -- 9662

Brick's picture
User offline. Last seen 2 years 12 weeks ago. Offline
Joined: 07/15/2008
Groups: Beta Folders
Different Reserve templates?

I looked at the reserve templates and they all looked identical, so I figured it was another puzzle set-up screw-up and didn't even try threading all those identical looking templates.

How would we know they are different without actually trying threading each one?

beta_helix's picture
User offline. Last seen 10 hours 25 min ago. Offline
Joined: 05/09/2008
Groups: None
All 9 server models have the same sequence, but are different!

I am sorry for not making this clear and thank you John McLeod for bring this up.

Since we are giving you 9 different server models for the same CASP target, the sequences of each server model will be the same: namely, the target sequence of that particular protein that has yet to be solved and released.

You can just load them all up randomly (by resetting the
puzzle a bunch of times) but during CASP many players mentioned that they wanted to be able to differentiate between the different multi-start models by name (to describe which one they had started from to other players for example).

For this reason (and also so you can use partial threading between 2 different server models, creating a hybrid model that might be even better!) we have placed these 9 starting models into the Template Reserve.

Although they all have exactly the same sequence and alignment score (since that particular score is based entirely on sequence) when you thread them they will be very different models.

I apologize for the confusion and will make this more clear for future CASP9 Revisited Puzzles!

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons