puzzle picture
366: Back Me Up 1
Status: Closed


Name: 366: Back Me Up 1
Status: Closed
Created: 09/27/2010
Points: 100
Expired: 10/03/2010 - 23:00
Difficulty: Intermediate
Description: We designed a helix to contact our substrate, but the helix needs back up to stay in place. The goal of this puzzle is to design a loop and mutate residues to create a more stable configuration, making a more active catalyst (ie create a Helix-Loop-Helix). See the blogpost for more details: http://fold.it/portal/node/988587

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marie_s's picture
User offline. Last seen 2 years 18 weeks ago. Offline
Joined: 05/18/2008
Groups: None
why ?

I cannot mutate segment insert on one end of the helix and I cannot delete segment ?

beta_helix's picture
User offline. Last seen 2 weeks 3 days ago. Offline
Joined: 05/09/2008
Groups: None
That is correct

We do not want you to change Alanine 54 or Glycine 55, however you are free to move the backbone there in order to make the helix move into a better position.

You cannot delete any residues, but you may add 0-5 residues anywhere between residues 44-54.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons