puzzle picture
359: Design the Pocket 1
Status: Closed


301christian.bauer 46 1458  13,0891
302cleardevice 46 1458  13,0891
303Q2_Amminadab 46 1458  13,0891
304piltrimin 46 1458  13,0891
305bmakanji 46 1458  13,0891
306ivan_h_g 46 1458  13,0891
307petrychio 46 1458  13,0891
308sgangid1 46 1458  13,0891
309Knusperfisch 46 1458  13,0891
310amille88 46 1458  13,0891
311Morbo 46 1458  13,0891
312garolle 46 1458  13,0891
313Orayesh 46 1458  13,0891
314msx36 46 1458  13,0891
315nbray1 46 1458  13,0891
316martinulm 46 1458  13,0891
317ekim79 46 1458  13,0891
318hfeng6 46 1458  13,0891
319yhuang56 46 1458  13,0891
320akim51 46 1458  13,0891
321linuxid10t 46 1458  13,0891
322asti 46 1458  13,0891
323cvdwilligen 46 1458  13,0891
324mcaparo1 46 1458  13,0891
325Carly Monto 46 1458  13,0891

Need this puzzle? Log in to download.  


Joined: 08/29/2010
Is it intentional that the

Is it intentional that the ligand is locked in place?

I'm a new player, but in the previous design puzzle it was possible to wiggle or manually pull the ligand into an optimal location. Right now, it still seems to be possible to wiggle it around but at a drastically reduced rate (.001 per second about, for as long as you care to let it run).

The result is that I've done about 15 seconds of design, and a few hours of letting it wiggle as it is the only way to move things.

beta_helix's picture
User offline. Last seen 4 days 23 hours ago. Offline
Joined: 05/09/2008
Groups: None
Everything is locked except for the designable sidechains

Unlike the previous design puzzles, we just want you to search for the sidechains that interact best with the ligand in this particular position.

I am sorry if that was unclear!

kbob's picture
User offline. Last seen 2 years 9 weeks ago. Offline
Joined: 09/03/2010
Groups: None
What's the ligand?

What's the ligand?

Miedzix's picture
User offline. Last seen 7 years 8 weeks ago. Offline
Joined: 08/17/2010

ligand is that "thing" in the middle of protein
more here : http://en.wikipedia.org/wiki/Ligand :P

Joined: 09/07/2010
Groups: None

Any suggestions on what to do once Mutate side chains and Wiggle do not give any effect?

beta_helix's picture
User offline. Last seen 4 days 23 hours ago. Offline
Joined: 05/09/2008
Groups: None
Mutate sidechains is the automated protocol, you must intervene

If you go into design mode and click on individual designable residues, you can mutate them manually.

This is where we need your help, because our computers can run "Mutate Sidechains" for hours and just get stuck. We are hoping that you can find interactions that "Mutate Sidechains" is unable to detect!

User login
Download links:
  Windows    OSX    Linux  
(10.12 or later)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media

Only search fold.it
Other Games: Mozak
Recommend Foldit
Top New Users

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons