puzzle picture
358 (<150): TNT Binding: Explosives made fun!
Status: Closed

Summary

Name: 358 (<150): TNT Binding: Explosives made fun!
Status: Closed
Created: 09/01/2010
Points: 100
Expired: 09/10/2010 - 23:00
Difficulty: Intermediate
Description: We've got another TNT binding puzzle for you guys! This time it's in a periplasmic binding protein. These proteins are very interesting due to their use in signal transduction systems and because they're fairly dynamic. You'll notice that the protein has a "hinge" in the middle of it (you can imagine the middle of the protein opening up like pac man). This region actually bends back and forth, opening up the binding site and closing it. The goal here is to design the closed protein state such that the TNT ligand will "bridge the gap" and cause the protein to snap shut. The hints mentioned in the previous TNT puzzle still apply and will be repeated in the comments section. For players with fewer than 150 global points.
Categories:

Top Groups

RankGroupScorePoints
1Anthropic Dreams9,703100
2Aotearoa's Assassins9,70360
3Russian team9,69534
4Crunching Family9,69019
5SETI.Germany9,67710

Top Soloists

RankPlayerGroupScorePoints
1spine123 74 1534  9,736100
2kpeterso 74 1534  9,71295
3Pod_289287 74 1534  9,71090
4nanodesu 74 1534  9,70886
5tola1 74 1534  9,70781


Need this puzzle? Log in to download.  

Comments

Joined: 09/08/2010
Groups: None
come si inizia a giocare?

come si inizia a giocare?

Fabio2's picture
User offline. Last seen 10 years 2 days ago. Offline
Joined: 05/21/2008
Groups: None
START

START HERE:
http://fold.it/portal/node/987307
Hopefully these instructions will help you!

E in italiano:
http://it.foldit.wikia.com/wiki/FoldIt_Wiki
Buon divertimento!

User login
Download links:
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.12 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media


Search
Only search fold.it
Other Games: Mozak
Recommend Foldit
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons