TNT?

Case number:845799-988295
Topic:Biochem
Opened by:spvincent
Status:Closed
Type:Question
Opened on:Friday, August 20, 2010 - 04:24
Last modified:Sunday, June 5, 2011 - 12:43

Is the orange-coloured ligand really TNT? It looks like trinitro-something but not toluene.

(Fri, 08/20/2010 - 04:24  |  3 comments)


beta_helix's picture
User offline. Last seen 6 hours 1 min ago. Offline
Joined: 05/09/2008
Groups: None
Type: Bug » Question

Austin will handle this one...

Joined: 10/10/2008
Groups: None

Ah! Good question. So it's very similar molecule to TNT, but ours has a linker coming off of it with a biotin molecule attached (not shown in the puzzle) so that we can more easily test for binding. We figure that since we are designing the protein to primarily bind the nitro groups and the ring, that free TNT should also bind if we can design a binder for this TNT-Biotin molecule.

-Austin

Joined: 06/17/2010
Status: Open » Closed

TNT puzzle gone, closing.

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