I am a pharmacist and PhD-student. Our working group has investigated extensively the nitric oxide sensitive guanylyl cyclase (EC 18.104.22.168, soluble guanylyl cyclase) for several years. The enzyme is a heterodimer formed by an α1- (with 690 AA) and a β1-subunit (with 619 AA). Until now there are only crystal structure known of parts of related proteins out of non-vertebrate species like Thermoanaerobacter tengcongensis, Nostoc punctiforme and Chlamydomonas reinhardtii. Due to the greatness of the enzyme (over 1.300 AA and 150 kDa) we are searching for an option to get some new information about the structure of the enzyme. I've found last week the paper in nature and was inspired by this. Is it possible to upload an own amino-acid sequence (we've create a fusion construct, so it would only be one sequence) and present it as a new puzzle, which can be solved by alle players?
With kind regards,