Strange side chain in 347

Case number:845799-988083
Topic:Biochem
Opened by:infjamc
Status:Closed
Type:Bug
Opened on:Monday, July 26, 2010 - 03:01
Last modified:Sunday, January 8, 2012 - 08:53

What's going on with this tyrosine? (I thought that the benzene ring is supposed to be flat.)

AttachmentSize
foldit_1280113149.png284.26 KB
(Mon, 07/26/2010 - 03:01  |  3 comments)


beta_helix's picture
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Joined: 05/09/2008
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Status: Open » Open

Thanks for catching this, infjamc.

This refinement model was generated by another human group competing in CASP9 (it's not a server model and it's definitely not a Rosetta model) and you can see for yourself if you download the PDB file from the CASP website (http://predictioncenter.org/casp9/target.cgi?id=175&view=refinement) that this error is in the model that they have given us.

We wanted to give you the exact file provided by CASP without messing around with it in any way, but it seems like making sure the PDB has ideal bond lengths and bond angles would be more important. After idealizing the starting model the tyrosine gets fixed, for example, so we could repost this puzzle but it might not be worth losing all the time you all have spent so far.

I will idealize future non-Rosetta refinement targets before posting them as Foldit puzzles, but for this case we can manually fix that Tyrosine before submitting this target to CASP.

Thanks again for catching this!

spmm's picture
User offline. Last seen 36 weeks 1 day ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
Status: Open » Closed

closed. Implemented, resolved, no comments or votes since 2010

spmm's picture
User offline. Last seen 36 weeks 1 day ago. Offline
Joined: 08/05/2010
Groups: Void Crushers

closed. Implemented, resolved, no comments or votes since 2010

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