Do most puzzles start with a fully unfolded protein (long chain)?
It seems that of the puzzles that are available (there aren't any beginner ones, it seems) are fully unfolded. But many of the "suggested methods" on the Wiki suggest global wiggle/shake as the first move (http://foldit.wikia.com/wiki/Pletsch's_Suggested_Method). This just seems to kinda bend the big long chain.
Are these puzzles best started with the alignment tool? Are the suggested methods for proteins that are already kinda folded?
Thanks for the help.