Guides, Alignment, and Use

Case number:845813-987382
Topic:Game: Tools
Opened by:Steven Pletsch
Opened on:Saturday, February 27, 2010 - 23:04
Last modified:Saturday, February 27, 2010 - 23:04

I would like to give a suggestion, and I know this is probably more than what you had intended, but I think it would be useful, and very powerful if implemented, though would require several changes.

1) Axis, Angle alignment tool for guides

This would allow you to take a loaded guide, pick 2 backbone segments on the protein to align the guide to, after doing so the software would draw an axis between the two segments on the guide, and another between the same two segments on the current protein, and place the guide centered axis to axis on the protein, then offer you a free arrow (similar to tweak tool perhaps) which would allow you to rotate the guide around the axis formed by the two points so that the guide can be aligned in a desirable fashion.

2) Partial alignment of structure with Alignment tool

Once given a a region that is properly aligned by the above tool, it would then be desirable to be able to choose only a portion of the sequence to line up with the alignment tool. So being able to lock off areas in the alignment tool which would not be changed would be really helpful.

3) Loading of arbitrary or preselected guides

Once these tools are available, it would also be much more powerful if on puzzles such as the blind targets, or the upcoming CASP targets, if either arbitrary puzzles could be loaded through URL or choosing a local file, or puzzles which were determined to have regions which are similar to the target were available from the server so that one could choose which guide to load to work on different areas of the puzzle.

Not sure if this is similar to intentions you may already have, but think this could be a very powerful addition to the game for both saving time, and exploring different options.


(Sat, 02/27/2010 - 23:04  |  0 comments)


Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons