puzzle picture
244: Mini-CASP 14-Freestyle
Status: Closed

Groups

RankGroupScorePoints
1Richard Dawkins Foundation10,237100
2Void Crushers10,18874
3Contenders10,13453
4Another Hour Another Point10,01038
5Russian team9,95627
6Free-DC9,79718
7SETI.Germany9,69413
89,6828
9ExPitneyFolders9,6776
10Crunching Family9,6634
11L'Alliance Francophone9,6022
12Natural Abilities9,4292
13Minions of TWIS9,3671
14Hungary9,3171
15sfb5799,2021
16Cedarburg H.S.9,1581
17turkish voluntered9,1421
18Boinc.be8,9931
19Czech National Team8,7871
20Rechenkraft.net8,4391
21DSN @ Home8,0431
22Ukraine8,0351
23Team China7,6251
24nothing better to do6,8101


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Comments

beta_helix's picture
User offline. Last seen 22 hours 7 min ago. Offline
Joined: 05/09/2008
Groups: None
secondary structure predictions will be here... eventually!

we would like to see how well you can do without any secondary structure predictions first, and then we will post the predictions for you here.

beta_helix's picture
User offline. Last seen 22 hours 7 min ago. Offline
Joined: 05/09/2008
Groups: None
Secondary structure prediction results:

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the amino acid Leucine at residue 61 is highly predicted to be part of a sheet. However, the Proline at residue 30 is predicted to have an equal probability of being anything!

Looks like you might have to unravel any helices!

Joined: 12/28/2009
Groups: None
Probability is for naught here

It seems to me - being a newbie and all - that this is exactly the kind of thing that we should not pay attention to as human folders.
We can't beat the number crushers at Rosetta et al using statistics, our advantage is the ability to look for patterns beyond statistics.
Essentially, we're looking for harmony and beauty, as far as this makes sense in this entirely novel discipline of visual protein folding?

beta_helix's picture
User offline. Last seen 22 hours 7 min ago. Offline
Joined: 05/09/2008
Groups: None
great point OmniDude!

Thanks for bringing this up OmniDude, this is exactly why we are running the Mini-CASP 15 - Freestyle A & B puzzles: so we can see how much the secondary structure predictions help you.

It could be the case that giving no guidance results in the best human predictions, as you say, but it could also be true that the search space is so large (which is why even all the number crushing currently done by Rosetta@home is not enough) that narrowing the search space so that humans don't have to focus on incorrect topologies might help!

We'll find out when the native structure is released!

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