puzzle picture
219: Hold On To Me
Status: Closed

Summary

Name: 219: Hold On To Me
Status: Closed
Created: 10/31/2009
Points: 100
Expired: 11/07/2009 - 23:00
Difficulty: Advanced
Description: Ever get a hankering for redesigning a glycerolphosphate synthase into a biotin binding protein? I sometimes do, which is why I've made this nice puzzle for you. This puzzle also has a single constraint meant to encourage the biotin tail to face outwards into the solvent. (Imagine a linker is attached at the tail end). You're allowed to move the backbone a little bit in this one too. SCORING: The ligand score is the primary contributor to the puzzle score. However, the other designable residues also contribute to a much less extend. Finally, the designable residues scores are also weighted based on their occurance in the multiple sequence alignment of the original scaffold.
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Top Groups

RankGroupScorePoints
1Contenders8,063100
2Richard Dawkins Foundation8,05476
3Natural Abilities8,05256
4SETI.Germany8,05041
5Void Crushers8,05030

Top Evolvers

RankPlayerGroupScorePoints
1mimi 78 1437 Contenders8,053100
2aendgraend 78 1437 SETI.Germany8,05097

Top Soloists



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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons