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Farnk's picture
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Joined: 10/31/2009
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so this question has probably be asked many times, but since I could not search the forum, i will ask again:

I guess you assume the lowest energy configurations are the actual configurations the proteins have.
Can we really assume that? Why could it not be that nature runs into a local minimum? Probably a god way to somehow check this, is to use proteins with a known structure and see if you can get a lower energy configuration. I would like to know, if you tried this and what the outcome was.
Thank you for your help!

Frank Schwemmer

Joined: 09/18/2009
Groups: SETI.Germany
The result was...

...that there were some solutions, which gave a better score than the natural solutions.
This started a discussion, if the score-calculating should be improved.




Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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