puzzle picture
216: Just Hold Me
Status: Closed


Name: 216: Just Hold Me
Status: Closed
Created: 10/30/2009
Points: 100
Expired: 11/07/2009 - 23:00
Difficulty: Advanced
Description: BIOTIN!! Now with 60% more fun! This time, the scaffold you'll design in is a rat intestinal fatty acid binding protein (PDB: 1icm). There is one constraint in place to encourage the biotin tail to face towards the solvent (because in most applications, biotin has a linker connected to that tail that needs to get out). You're allowed to move the backbone a little bit , but don't overuse that backbone wiggle or else you'll have a hard time getting it back. (Use sidechain wiggle instead) SCORING: The ligand score is the primary contributor to the puzzle score. However, the other designable residues also contribute to a much less extend. Finally, the designable residues scores are also weighted based on their occurance in the multiple sequence alignment of the original scaffold.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons