As a non-chemist, I'm trying to fold my brain around proteins, and I was wondering about two aspects of the scoring.
First, hydropathy. Leucine is more hydrophobic than alanine. In FoldIt, is it generally more harmful to your score to have leucine exposed than to have alanine sticking out?
Second, polarity. Is this factored into FoldIt? Do polar opposites attract?
Any light you can shed on this for me would be greatly appreciated!