I've been developing a distributed computing project called Hydrogen@Home where I am investigating methods for identifying or designing enzymes for biological hydrogen production. Recently I have gotten a better understanding of rosetta and distributed thinking projects as manifested by this project. I am also familiar with methods for predicting transition state structures for chemical reactions. Many of these predictions require a degree of chemical intuition. Without getting into too many details, I would like to explore using this paradigm to assist in my research.