I thought it would be good to start a thread with some basic tips for people to use in playing the game. It is certainly much more enjoyable when you have a feel for what you are doing. I don't really scientifically know what I'm doing. But I've been studying Rosetta for a long time. And spiralling those native sturctures around trying to see patterns from one protein to the next. And I seem to be scoring well, so I thought I would share some about things that seem to be working for me. I hope others will do the same and post their ideas here. Some combination of all of them will ultimately be a better approach.
In fact, let's make it a standing rule that if you take the top score when a puzzle is closed, you have to post a tip to this thread.