Well, I'm not even sure this is the right place for it, but I'm concerned that using Fold It, or Fold@Home, might burden my ISP.
I've heard that some ISPs cap downloads to a few gigs per month. I'm unsure what the limit for mine would be, if one even exists.
Is the majority of the processing done on my machine with very little in the way of downloading? And with higher strain on my processor, will it cause my electricity bill to go up? Because while I'm just dandy about having my machine mathmatically solve problems, burdening my provider with hefty downloads is something I'm not so keen on.
These are all questions that I acknowledge as ignorant on my behalf.