|
|
|
2172: CD47 Binder Design: Round 11
Status: Closed
|
Evolvers
|
| 1 | Galaxie 1 2 | Anthropic Dreams | 14,286 | 100 | | 2 | LociOiling 2 1 | Anthropic Dreams | 14,205 | 94 | | 3 | alcor29 5 8 | Anthropic Dreams | 14,188 | 88 | | 4 | phi16 10 43 | Anthropic Dreams | 14,136 | 82 | | 5 | MrZanav 12 48 | Anthropic Dreams | 14,095 | 76 | | 6 | Dhalion 26 302 | Go Science | 13,934 | 71 | | 7 | NinjaGreg 24 19 | Go Science | 13,926 | 66 | | 8 | Bruno Kestemont 4 5 | Go Science | 13,919 | 61 | | 9 | HuubR 23 54 | Gargleblasters | 13,909 | 56 | | 10 | Anfinsen_slept_here 13 37 | Go Science | 13,902 | 52 | | 11 | Sandrix72 8 6 | Go Science | 13,893 | 48 | | 12 | silent gene 31 71 | Go Science | 13,892 | 45 | | 13 | Beany 19 38 | Gargleblasters | 13,769 | 41 | | 14 | MicElephant 7 13 | Contenders | 13,586 | 38 | | 15 | BootsMcGraw 11 10 | Contenders | 13,578 | 35 | | 16 | maithra 6 22 | Contenders | 13,573 | 32 | | 17 | Bletchley Park 9 14 | Contenders | 13,550 | 30 | Need this puzzle? Log in to download.
Comments
|
|
|
|
|
|
|
|
|
|
|
|
DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.
Contact Surface (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.
Buried Unsats (max +500)
Penalizes 20 points for each polar atom that cannot make any hydrogen bonds.
Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Disabled use of CYS residues.
Neural Net (max +0)
Achieve an AlphaFold prediction confidence of 80% or more.