puzzle picture
2172: CD47 Binder Design: Round 11
Status: Closed

Groups

RankGroupScorePoints
1Anthropic Dreams14,286100
2Go Science13,93468
3Gargleblasters13,91244
4Marvin's bunch13,67127
5Contenders13,58616
6Void Crushers13,3969
7Team China12,8215
8Australia12,7353
9L'Alliance Francophone11,6001
10AlphaFold9,6611
11Beta Folders4,6981
12DU Proteins S2001
13Boilermakers01
14Window Group01


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bkoep's picture
User offline. Last seen 20 hours 28 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.

Contact Surface (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.

Buried Unsats (max +500)
Penalizes 20 points for each polar atom that cannot make any hydrogen bonds.

Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Disabled use of CYS residues.

Neural Net (max +0)
Achieve an AlphaFold prediction confidence of 80% or more.

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