I'm getting 17434 points with the monomer being a single long helix (and 95% Alphafold confidence).
Nice, 17k points is impressive! The reason for the 50% helix penalty is to encourage players to design diverse, non-helix folds.
A single long alpha helix (a.k.a. "megahelix") tends to have a very low energy, and is also a common fold for any hydrophilic sequences. For this reason, a megahelix design tends to have a good Foldit score and a high AlphaFold confidence.
However, megahelix designs tend to be poorly behaved in reality. The lack of long-range, tertiary interactions means that the helix can partially unfold without a large energy penalty. Most of the time, the protein exists in a partially-folded state.
In contrast, a compact and globular fold is held together with lots of tertiary interactions. Even partial unfolding will disrupt many of those interactions and incur a large energy penalty. This usually means the protein will be well-behaved, and is very stable in its completely-folded state.
This bonus is actually 3000pts instead of the here written 2400pts. This should be expected sind we have now 5 units (monomer + 4 copies). Seems to be a copy&paste error from a Tetramer-Puzzle :)
Good catch!
Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -250 points per atom (not including symmetric copies).
Core Existence: Monomer (max +2200)
Ensures that at least 22 residues are buried in the core of the monomer unit.
Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.
H-bond Network (max
+2400+3000)Rewards networks that comprise at least 2 H-bonds involving core residues.
Between 1 and 15 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
SS Design (max +500)
Penalizes all CYS residues.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.
Neural Net (max +0)
Achieve an AlphaFold prediction confidence of 80% or more.