Make blueprint mutate protein so it will Alphafold out of the box
|Opened on:||Sunday, May 1, 2022 - 19:08|
|Last modified:||Monday, May 2, 2022 - 18:23|
Right now if you use the blueprint tool, it shapes your protein, but it does not
mutate it appropriately -- in particular loops are generated with all "i" residues,
which AlphaFold completely ignores. If the blueprint tool mutated the loops be Gly etc.
when it made them so they would actually be a) ideal loops and b) ones that AlphaFold
would recognize, as a loop transition, it would make life much easier. Similarly if
sheets are mutated to a segment type that AlphaFold knows are sheets and not helices,
that would be nice.
Basically, the test is: if I make a 4 by 4 sheet with two helixes on the back in
the blueprint tool, and submit it to alphaflow, it should really fold up that way.
As its stands, no matter what you make in the blueprint tool, it comes out as one
long helix in alphaflow.