Lab Report #32: Good Rotations

Collaborators are now testing VHL ligand designs in the lab, and new software features put the focus on rotatable bonds to help us create more effective molecules.

NEWS
- Lab testing VHL ligand designs
- New tools for ligand design

PUZZLE UPDATES
- KLHDC2 ligand design

DESIGN OF THE MONTH
- A CD47 binder design by alcor29 in Puzzle 2132. The binding interface features a balance of hydrophobics (for tight binding) and polar sidechains (for folding and BUNS satisfaction). See for yourself in the Design of the Month sandbox puzzle.

(Sun, 05/01/2022 - 13:28  |  0 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons