|
|
|
2135: TGF Receptor Binder Design: Round 17
Status: Closed
|
Evolvers
|
| 1 | Bruno Kestemont 4 6 | Go Science | 11,320 | 100 | | 2 | Galaxie 1 2 | Anthropic Dreams | 11,285 | 94 | | 3 | LociOiling 2 1 | Anthropic Dreams | 11,276 | 87 | | 4 | gmn 3 3 | Anthropic Dreams | 11,273 | 81 | | 5 | ichwilldiesennamen 25 10 | Go Science | 11,223 | 76 | | 6 | phi16 10 41 | Anthropic Dreams | 11,195 | 70 | | 7 | alcor29 5 8 | Anthropic Dreams | 11,165 | 65 | | 8 | robgee 16 21 | Anthropic Dreams | 11,165 | 60 | | 9 | Cyberkashi 23 135 | Anthropic Dreams | 11,077 | 56 | | 10 | MrZanav 11 45 | Anthropic Dreams | 11,060 | 52 | | 11 | nspc 40 31 | Go Science | 11,047 | 48 | | 12 | maithra 6 23 | Contenders | 10,955 | 44 | | 13 | spvincent 31 9 | Contenders | 10,938 | 41 | | 14 | BootsMcGraw 12 12 | Contenders | 10,878 | 37 | | 15 | Bletchley Park 9 14 | Contenders | 10,845 | 34 | | 16 | Oransche 21 106 | Marvin's bunch | 10,157 | 32 | Need this puzzle? Log in to download.
Comments
|
|
|
|
|
|
|
|
|
|
|
|
DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.
Contact Surface (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.
Buried Unsats (max +500)
Penalizes 20 points for each polar atom that cannot make any hydrogen bonds.
Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Disabled use of CYS residues.
Neural Net (max +0)
Achieve an AlphaFold prediction confidence of 80% or more.