puzzle picture
Successful Binder Design Sandbox
Status: Closed

Summary

Name: Successful Binder Design Sandbox
Status: Closed
Created: 04/05/2022
Points: 0
Expired: 04/30/2022 - 23:00
Difficulty: Intermediate
Description: This sandbox puzzle features three successful protein binders designed by scientists in this recent research paper. There are three starting structures, showing designed binders for CD3-delta, FGF receptor 2, and IGF1 receptor. Reset the puzzle to cycle through the different starting structures. For more, check out Foldit Lab Report #31 on YouTube! This sandbox puzzle is non-competitive and will not award any points.
Categories:

Top Groups

RankGroupScorePoints
1Anthropic Dreams12,6580
2Go Science12,4940
3Marvin's bunch12,2310
4L'Alliance Francophone12,2050
5AlphaFold12,0550

Top Soloists

RankPlayerGroupScorePoints
1LociOiling 2 1 Anthropic Dreams12,6580
2zippyc137 74 16  12,6080
3Aubade01 74 40  12,5720
4WBarme1234 74 21  12,5040
5ichwilldiesennamen 23 10 Go Science12,4940


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Comments

LociOiling's picture
User offline. Last seen 6 hours 11 min ago. Offline
Joined: 12/27/2012
reposted puzzle gives errors

When I try to load a pose from the previous version of this puzzle, I get the error:

Error in sequence mapping size. Attempted to load pose of size 163 into a puzzle of size 124.
Aubade01's picture
User offline. Last seen 1 day 12 hours ago. Offline
Joined: 10/12/2013
Groups: None
puzzle error

I got the same error attempting to reload a previous save.

>>>>> Aubade00/01

bkoep's picture
User offline. Last seen 10 hours 13 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Bug

Hmm, this look like a bug with multi-start puzzles, and unfortunately I don't have a solution for it right now. Your old solutions may be "trapped" in the expired puzzle.

If you want to continue working with those solutions, you will have to do so in the expired puzzle. Beware that the expired puzzle is not fully compatible with a forthcoming update, and Foldit may crash if you try to share solutions between devprev and main clients.

toshiue's picture
User offline. Last seen 4 hours 48 min ago. Offline
Joined: 01/31/2016
Groups: Go Science
scoreboard not updating

Has the scoreboard been halted then? I'm at 12,558 and still showing 11,995 on the scoreboard.

bkoep's picture
User offline. Last seen 10 hours 13 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Hmm

That is strange. You're playing online? I wonder if your client is having trouble reaching the server. You may try saving your solution and restarting Foldit.

Also worth double checking that you are not playing the expired version of this puzzle. Yesterday we closed and reposted the original Successful Binder Design Sandbox puzzle in preparation of a software update.

toshiue's picture
User offline. Last seen 4 hours 48 min ago. Offline
Joined: 01/31/2016
Groups: Go Science
Thanks bkoep

Thanks, will try both.

toshiue's picture
User offline. Last seen 4 hours 48 min ago. Offline
Joined: 01/31/2016
Groups: Go Science
Didn't work, error message

Saved and closed both solo clients. Reloaded puzzle and got an error message on both clients when I reloaded my saved scores.
"Error in sequence mapping size. Attempted to load pose 203 into a puzzle of size 124."
Frozen. Won't load any.

toshiue's picture
User offline. Last seen 4 hours 48 min ago. Offline
Joined: 01/31/2016
Groups: Go Science
same fundamental problem

as Loci and Aubade01 had. Started over, that was an equally bad mess. Quitting the puzzle.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons