Lab Report #31: Breaking it down
A new paper shows how scientists can now make proteins that bind a bunch of different targets. How did they do it — and what does this breakthrough mean for Foldit? In this video, we breakdown a recent breakthough in protein design.
- Binder design for CD22, TGF-beta receptor, and other hard targets
- Electron density reconstruction
- Small molecule design
- Symmetric protein design
DESIGN OF THE MONTH
- A symmetric tetramer design by BootsMcGraw in Puzzle 2121. Boots uses an extensive H-bond Network to satisfy buried polar residues at the symmetric interface. See for yourself in the Design of the Month sandbox puzzle.