Lab Report #31: Breaking it down

A new paper shows how scientists can now make proteins that bind a bunch of different targets. How did they do it — and what does this breakthrough mean for Foldit? In this video, we breakdown a recent breakthough in protein design.

NEWS
- Reviewing new research about protein binder design
- Explore successful binders in this special sandbox puzzle.

PUZZLE UPDATES
- Binder design for CD22, TGF-beta receptor, and other hard targets
- Electron density reconstruction
- Small molecule design
- Symmetric protein design

DESIGN OF THE MONTH
- A symmetric tetramer design by BootsMcGraw in Puzzle 2121. Boots uses an extensive H-bond Network to satisfy buried polar residues at the symmetric interface. See for yourself in the Design of the Month sandbox puzzle.

(Fri, 04/01/2022 - 14:26  |  0 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons