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2118: TGF Receptor Binder Design: Round 16
Status: Closed
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Evolvers
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| 1 | Bletchley Park 9 14 | Contenders | 11,280 | 100 |
| 2 | maithra 6 23 | Contenders | 11,259 | 95 |
| 3 | LociOiling 2 1 | Beta Folders | 11,234 | 89 |
| 4 | Galaxie 1 2 | Anthropic Dreams | 11,229 | 84 |
| 5 | gmn 3 3 | Anthropic Dreams | 11,222 | 79 |
| 6 | Bruno Kestemont 4 6 | Go Science | 11,211 | 74 |
| 7 | Cyberkashi 23 135 | Contenders | 11,196 | 70 |
| 8 | georg137 30 151 | Contenders | 11,179 | 65 |
| 9 | robgee 16 21 | Anthropic Dreams | 11,176 | 61 |
| 10 | alcor29 5 8 | Anthropic Dreams | 11,161 | 57 |
| 11 | phi16 10 41 | Anthropic Dreams | 11,055 | 54 |
| 12 | kyoota 13 61 | Go Science | 10,948 | 50 |
| 13 | BootsMcGraw 12 12 | Contenders | 10,602 | 47 |
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Comments
DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.
Contact Surface (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.
Buried Unsats (max +500)
Penalizes 10 points for each polar atom that cannot make any hydrogen bonds.
Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Disabled use of CYS residues.
Neural Net (max +0)
Achieve an AlphaFold prediction confidence of 80% or more.