2106: Design with Neural Net Objective
|Name:||2106: Design with Neural Net Objective|
|Expired:||02/16/2022 - 23:00|
|Description:||Design a protein with the help of the new Neural Net Objective! The Neural Net Objective can help identify parts of your protein that should be mutated to improve AlphaFold prediction confidence. After you use the AlphaFold tool to get a prediction, click "Show Neural Net Objective" to color your protein based on local distogram analysis. To improve AlphaFold prediction confidence, try mutating residues that are colored red by the Neural Net Objective. Players should aim for an AlphaFold confidence and similarity of 80% or more.
We are especially interested to see what creative new folds players might come up with. There are no additional Objectives, but we expect successful designs will still need lots of helices or sheets, with short minimal loops, as well as a closely-packed core of orange hydrophobic residues. AlphaFold predictions will not affect your score. Players may insert and delete residues to a maximum of 120 residues total.
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