Why can't I upload to Alphafold for closed puzzles ?

Case number:845813-2012583
Topic:Game: Tools
Opened by:Bletchley Park
Status:Open
Type:Question
Opened on:Saturday, December 25, 2021 - 06:54
Last modified:Tuesday, December 28, 2021 - 11:37

I liked to get the Alphafold score for the latest tetramer after it closed. AF did not allow me to upload the final solution because 'Alphafold solutions can only be submitted for open puzzles', Why ?

(Sat, 12/25/2021 - 06:54  |  2 comments)


bkoep's picture
User offline. Last seen 1 day 3 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

We want to avoid frivolous use of the AlphaFold server, so AlphaFold submissions are disabled for closed puzzles.

The server that runs AlphaFold is a limited, shared resource; other researchers rely on the same GPUs for their own research. We want to be sure we are using this resource responsibly and productively, so Foldit only accepts AlphaFold submissions for active puzzles.

There is a bit more discussion in this previous feedback.

Joined: 05/19/2009
Groups: Contenders

Thank you for clarifying, the suggestion you gave in the other post will also work:

"If you want to explore AlphaFold predictions for arbitrary sequences, I recommend using the AlphaFold Google Colab notebook. The Colab notebook will also allow you use natural sequence alignments (this is disabled for the Foldit AlphaFold tool); this will likely give you better and more consistent predictions for natural protein sequences. "

Regards, BP

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