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2084: Symmetric Tetramer Design with AlphaFold Predictions
Status: Closed
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Soloists
1 | spvincent 30 13 | Contenders | 21,133 | 100 | 2 | ichwilldiesennamen 24 11 | Go Science | 21,125 | 95 | 3 | HuubR 36 80 | Gargleblasters | 21,023 | 90 | 4 | Bruno Kestemont 3 3 | Go Science | 20,867 | 85 | 5 | LociOiling 2 1 | Beta Folders | 20,802 | 81 | 6 | sgeldhof 46 76 | | 20,710 | 76 | 7 | silent gene 46 493 | Go Science | 20,680 | 72 | 8 | ZeroLeak7 32 28 | Go Science | 20,603 | 68 | 9 | Galaxie 1 2 | Anthropic Dreams | 20,504 | 64 | 10 | gmn 4 5 | Anthropic Dreams | 20,357 | 61 | 11 | grogar7 37 37 | Anthropic Dreams | 20,268 | 57 | 12 | BootsMcGraw 10 9 | Contenders | 20,173 | 54 | 13 | alcor29 5 7 | Anthropic Dreams | 20,104 | 51 | 14 | Punzi Bake... 46 54 | | 20,070 | 48 | 15 | dcrwheeler 46 4 | | 19,492 | 45 | 16 | WBarme1234 46 26 | | 19,378 | 42 | 17 | phi16 11 32 | Anthropic Dreams | 19,215 | 39 | 18 | robgee 7 10 | Anthropic Dreams | 18,996 | 37 | 19 | Bautho 46 296 | Go Science | 18,799 | 35 | 20 | akaaka 46 17 | | 18,641 | 32 | 21 | jamiexq 38 68 | Anthropic Dreams | 18,546 | 30 | 22 | zippyc137 46 16 | | 18,488 | 28 | 23 | Bletchley Park 9 8 | Contenders | 18,348 | 26 | 24 | fpc 16 25 | Marvin's bunch | 18,138 | 25 | 25 | georg137 22 56 | Contenders | 17,941 | 23 | Need this puzzle? Log in to download.
Comments
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Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -200 points per atom (not including symmetric copies).
Core Existence: Monomer (max +2000)
Ensures that at least 20 residues are buried in the core of the monomer unit.
Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.
H-bond Network (max +2400)
Rewards networks that comprise at least 2 H-bonds involving core residues.
Between 1 and 12 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.