puzzle picture
2084: Symmetric Tetramer Design with AlphaFold Predictions
Status: Closed

Groups

RankGroupScorePoints
1Contenders21,276100
2Go Science21,12571
3Gargleblasters21,02349
4Beta Folders20,80233
5Anthropic Dreams20,50422
6Marvin's bunch18,13814
7L'Alliance Francophone16,7238
8Russian team16,1805
9Australia15,4773
10SETI.Germany15,4292
11Void Crushers13,0461
12Czech National Team12,5711
13Italiani Al Lavoro12,2661
14foldeRNA01
15Team Canada01
16Foldit Staff01


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bkoep's picture
User offline. Last seen 14 hours 35 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -200 points per atom (not including symmetric copies).

Core Existence: Monomer (max +2000)
Ensures that at least 20 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +2400)
Rewards networks that comprise at least 2 H-bonds involving core residues.
Between 1 and 12 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons