puzzle picture
2078: CD47 Binder Design: Round 5
Status: Closed

Groups

RankGroupScorePoints
1Anthropic Dreams13,613100
2Go Science13,53470
3Beta Folders13,11847
4Marvin's bunch12,93030
5Contenders12,86719
6Gargleblasters12,86111
7Void Crushers12,3027
8L'Alliance Francophone11,5314
9Russian team11,4212
10AlphaFold11,3191
11Australia10,9441
12Italiani Al Lavoro10,2671
13Czech National Team8,3771
14Team China7,6091
15Foldit Staff01


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bkoep's picture
User offline. Last seen 1 day 3 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.

Contact Surface (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.

Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.

Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets and helices.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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