Foldit Drug Design (aka Drugit)

We are embarking on a bold new journey to bring Small Molecule Drug Design to the creative minds of the citizen science community. By teaming up with Boehringer Ingelheim, a major pharmaceutical company, Small Molecule Drug Design has been brought to Foldit. We are running a series of Small Molecule puzzles, and Boehringer Ingelheim has committed to help evaluate then synthesize and test the best molecules that players design. To learn more check out the Small Molecule Design Project

Download the Game
- Download for Windows
- Download for Mac
- Download for Linux

Account Creation
- To get started, create an account by selecting Create new account.

Downloading the Game Client
- Select the download link that matches your operating system on the right hand side of this page.

Finding the Small Molecule Puzzles

- Once the game is running you will be asked to play online or offline.
- Select Play Online and sign in.
- Select Science Puzzles.
- The current Small Molecule Drug Design Puzzles will automatically appear in your puzzle selection menu shown below:

Current Small Molecule Drug Design Puzzle:

- To be announced.

Getting started with the Small Molecule Drug Design Tool:

- Small Molecule Drug Design Tool

Additional Small Molecule Drug Design Information:

- Small Molecule Drug Design Wiki

Getting started with the Foldit User Interface:

- User Interface

Hints of the Week:

- To start building your small molecule, first select the small molecule by left clicking it then select the 'Design Ligand!' from the actions bar at the bottom of the screen.

Previous Small Molecule Drug Design Puzzles:
- 2091: VHL ligand design: Round 10
- 2088: VHL ligand design: Round 9
- 2082: VHL ligand design: Round 8
- 2082: VHL ligand design: Round 7
- 2079: VHL ligand design: Round 6
- 2074b:VHL ligand design: Round 5b
- 2074: VHL ligand design: Round 5
- 2071: VHL ligand design: Round 4
- 2068: VHL ligand design: Round 3
- 2062: VHL ligand design: Round 2
- 2059: VHL ligand design: Round 1

Lab Report #26: Small Molecule Design

Lab Report #27: Foldit's New User Interface

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons