Information about the objectives in this puzzle. (All objectives give +1000 points when fully satisfied.)

• HBond - A large bonus for making a hydrogen bond to the serine and the histidine in the center of the pocket. (Click "Show" to highlight the atom needing the hydrogen bond.)
• Buried Unsats - Penalizes polar atoms that cannot make hydrogen bonds
• Bad Groups - Gives a bonus for avoiding groups we're interested in removing, including enol, enamine, thiocarbonyl, hydroxylamines, geminal diols, charged nitrogens, and alpha-beta unsaturated carbonyls. Also rewards avoiding a hydroxyproline-like solution to the HBond filter.
• Ligand cLogP - A measure of polarity - Keeps the molecule from getting too hydrophobic
• Ligand TPSA - Topological Polar Surface Area - Keeps the polar surface area (including buried polar surface) low.
• Ligand Hydrogen Bond Donors - Keep the number of ligand hbond donors low.
• Molecular Weight - Intended to keep the ligand from getting too big.
• Number of Rotatable Bonds - Intended to keep the ligand from getting too big and floppy.
• Ligand Substructure - Identify areas of the small molecule which aren't very drug-like.
• Synthetic Accessibility - Identify molecules which are likely to be hard to make in the lab.

Most objectives have a "Show" button which should highlight areas of concern in red. (Even when fully satisfied, objectives may highlight groups which may eventually contribute.)