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2065: Symmetric Trimer Design with AlphaFold Predictions
Status: Closed
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Soloists
1 | LociOiling 2 1 | Beta Folders | 24,121 | 100 | 2 | grogar7 46 19 | Anthropic Dreams | 23,684 | 95 | 3 | ichwilldiesennamen 22 10 | Go Science | 23,467 | 90 | 4 | silent gene 24 78 | Go Science | 23,340 | 85 | 5 | sgeldhof 46 39 | | 23,271 | 80 | 6 | HuubR 30 63 | Gargleblasters | 22,980 | 76 | 7 | Galaxie 1 2 | Anthropic Dreams | 22,861 | 72 | 8 | Bruno Kestemont 3 3 | Go Science | 22,632 | 68 | 9 | spvincent 29 11 | Contenders | 22,590 | 64 | 10 | phi16 9 30 | Anthropic Dreams | 22,380 | 60 | 11 | dcrwheeler 46 4 | | 22,183 | 56 | 12 | alcor29 5 9 | Anthropic Dreams | 22,100 | 53 | 13 | robgee 7 6 | Anthropic Dreams | 22,099 | 50 | 14 | BootsMcGraw 10 8 | Contenders | 22,089 | 47 | 15 | infjamc 33 21 | Contenders | 22,011 | 44 | 16 | gmn 4 5 | Anthropic Dreams | 21,679 | 41 | 17 | Maerlyn138 46 1603 | Go Science | 21,509 | 39 | 18 | akaaka 46 17 | | 20,999 | 36 | 19 | Skippysk8s 34 28 | Gargleblasters | 20,963 | 34 | 20 | NinjaGreg 37 15 | Go Science | 20,806 | 32 | 21 | fiendish_ghoul 46 36 | | 20,355 | 29 | 22 | Bautho 46 286 | Go Science | 20,238 | 27 | 23 | zippyc137 46 16 | | 20,116 | 26 | 24 | kyoota 11 44 | Go Science | 19,851 | 24 | 25 | eusair 46 1603 | | 19,841 | 22 | Need this puzzle? Log in to download.
Comments
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Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -150 points per atom (not including symmetric copies).
Core Existence: Monomer (max +3000)
Ensures that at least 30 residues are buried in the core of the monomer unit.
Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.
H-bond Network (max +1800)
Rewards networks that comprise at least 2 H-bonds involving core residues.
Between 1 and 9 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.