Intro to design appears to be unsolvable.

Case number:671071-2012259
Topic:Game: Other
Opened by:JiuJitsuJunkie
Opened on:Saturday, October 23, 2021 - 20:15
Last modified:Monday, October 25, 2021 - 16:51

There is no arrangement or amino acid choice that will allow successful completion of the task

(Sat, 10/23/2021 - 20:15  |  1 comment)

rmoretti's picture
User offline. Last seen 1 day 23 min ago. Offline
Joined: 01/15/2010
Groups: Foldit Staff

As hinted by the text, you should be able to get a better score by reducing the size of the two red amino acids.

There should be several combinations which give a passing score, but the "simple" approach of reducing the size by mutating both to Alanine - ALA(A) - should meet the requirement. It's not the best combination, but it should pass the threshold. (While Glycine - GLY(G) - is even smaller than Alanine there are energetic reasons related to backbone structure why it's not a good choice in this situation.)


Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons