|
|
|
2058: TGF Receptor Binder Design: Round 12
Status: Closed
|
Soloists
|
| 51 | kentish_alex 46 533 | | 6,893 | 1 | | 52 | DScott 46 124 | | 6,608 | 1 | | 53 | Hellcat6 41 89 | Go Science | 6,458 | 1 | | 54 | pascal ochem 46 1390 | Go Science | 6,256 | 1 | | 55 | Oransche 19 69 | Marvin's bunch | 5,735 | 1 | | 56 | vybi 46 317 | Czech National Team | 5,642 | 1 | | 57 | Caraline_nelson 46 1390 | Go Science | 5,397 | 1 | | 58 | Trajan464 46 85 | | 5,336 | 1 | | 59 | puxatudo 46 1390 | Go Science | 5,308 | 1 | | 60 | Jenot96 46 1390 | | 4,945 | 1 | | 61 | fabiodavilla 46 1390 | | 4,929 | 1 | | 62 | rezaefar 46 122 | | 4,857 | 1 | | 63 | gianbomb 46 1390 | | 3,841 | 1 | | 64 | Mohoernchen 46 156 | | 3,827 | 1 | | 65 | furi0us 46 189 | | 3,605 | 1 | | 66 | artsyambie6 46 348 | | 3,447 | 1 | | 67 | Enzyme 46 1390 | Gargleblasters | 2,767 | 1 | | 68 | Belle36 46 1390 | | 2,126 | 1 | | 69 | Clement Wong 46 830 | Team China | 0 | 1 | | 70 | Dr RAS 46 1390 | | 0 | 1 | | 71 | ebenhoch 46 1390 | | 0 | 1 | | 72 | 01010011111 46 491 | Go Science | 0 | 1 | | 73 | Bletchley Park 8 7 | Contenders | 0 | 1 | | 74 | guineapig 23 14 | | 0 | 1 | | 75 | jausmh 17 29 | Marvin's bunch | 0 | 1 | Need this puzzle? Log in to download.
Comments
|
|
|
|
|
|
|
|
|
|
|
|
DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.
Contact Surface (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.
Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.
Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets and helices.