puzzle picture
2040: IL-2R Binder Design: Round 5 with AlphaFold Predictions
Status: Closed

Groups

RankGroupScorePoints
1Gargleblasters14,046100
2Go Science13,84968
3Beta Folders13,70444
4Anthropic Dreams13,64027
5Contenders13,59716
6Void Crushers13,1939
7Australia12,6405
8Marvin's bunch11,8413
9L'Alliance Francophone11,5011
10BOINC@Poland11,4171
11Nessun Dorma11,1101
12AlphaFold9,9871
13Rechenkraft.net8,0011
14Foldit Staff6,3931


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bkoep's picture
User offline. Last seen 8 hours 43 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.

Contact Surface (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.

Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.

Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets and helices.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons