Blueprint Tool doesn''t always show the right sequence and secondary structure
| Case number: | 845813-2012020 |
| Topic: | Game: Tools |
| Opened by: | jeff101 |
| Status: | Open |
| Type: | Bug |
| Opened on: | Friday, September 3, 2021 - 16:22 |
| Last modified: | Thursday, September 9, 2021 - 02:09 |
I've been using a Foldit client with the
updates below on a Windows 10 Laptop:
buildid: 20210831-bed0d5b3c9-win_x86-devprev
cmp-binary-33ed74bbc2dd179d9edeededfa1d3eb2
cmp-database-72f92029fef65449f12c85b437bf8d06
cmp-resources-3058579f85fcf6a7290a80a16cf8c0c2
At some point I noticed that in the
Original Interface, the primary and secondary
structures shown in the Blueprint Tool were
incorrect. There were even times when the
secondary structure was correct, but the
primary structure (protein sequence) was
incorrect. Sometimes I was able to fix these
problems by starting a Recipe, closing and
reopening the Blueprint Tool, or freezing and
unfreezing the protein, but it was enough to
cause confusion.
Please change the code so that the Blueprint
Tool automatically updates itself more often
and more completely so it is more likely to
show the latest primary and secondary
structures for the protein.
Thanks!»
Wed, 09/08/2021 - 22:20
#2
Hi Jeff,
I looked into this and I was able to see the blueprint panel not updating as mutate is running. However, I believe that is the intended behavior. The blueprint panel updates when the mutate ends. As for secondary structure mismatch, I haven't been able to reproduce that. I tried using scripts and selection mode. Are you still seeing this, and if so could you provide steps to reproduce?
Thanks,
milkshake
Thu, 09/09/2021 - 02:09
#3
For Puzzle 2038, make 2 designs with different primary sequences
and desired secondary structures. Save both of these structures
as ir_solution files. Next open the Blueprint Tool in the Original
Interface. Next load one of the solutions. You should see its
sequence and secondary structure in the Blueprint Tool. Next load
the other solution. Often this solution looks wrong in the Blueprint
Tool until I do freeze/unfreeze or start a recipe. Then it switches
to the correct primary and secondary structures.
It helps to view as cartoon, color w/abego, and Tab on different
segments of the protein. Sometimes these things disagree with what
the Blueprint Tool is showing. When they agree, take a screenshot
with the Blueprint Tool and 3D structure of the protein showing.
This will help as you try to replicate the problem.
If you need more details, please e-mail me via the Foldit site.
Thanks, & Good luck!
If it matters, I made the above observations in Puzzle 2038.