2027: Design with AlphaFold Predictions
|Name:||2027: Design with AlphaFold Predictions|
|Expired:||08/31/2021 - 23:00|
|Description:||Design a protein with the help of the new AlphaFold prediction tool! AlphaFold is an algorithm from the company DeepMind and can predict protein structures with incredible accuracy. We want to know if Foldit players can use feedback from AlphaFold to design new proteins! After you've designed a protein, you can upload your solution to the Foldit server and get back an AlphaFold prediction about how your design will actually fold up. Players should aim for an AlphaFold confidence and similarity of 80% or more. See the blog for more details about the AlphaFold prediction tool.
We are especially interested to see what creative new folds players might come up with. We already know that Foldit players can design simple helix bundles or ferredoxin-like ("surfing hotdog") proteins. We are hoping that AlphaFold will allow players to explore protein designs with all beta sheets, or folds with a recessed binding pocket where a ligand could fit. After this puzzle closes, we'll highlight our favorite designs in the next Lab Report video update on September 1.
In addition to the typical extended chain, this puzzle has four starting structures of designed proteins that you may like to use as a starting point. Reset the puzzle to cycle through the different starting structures. There are no Objectives, but we expect successful designs will still need lots of helices or sheets, with short minimal loops, as well as a closely-packed core of orange hydrophobic residues. AlphaFold predictions will not affect your score. Players may insert and delete residues to a maximum of 120 residues total. This special puzzle will remain online until August 31 at 23:00 GMT.
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