puzzle picture
2021: Symmetric Trimer Design: H-bond Networks
Status: Closed

Summary

Name: 2021: Symmetric Trimer Design: H-bond Networks
Status: Closed
Created: 07/21/2021
Points: 100
Expired: 07/28/2021 - 23:00
Difficulty: Intermediate
Description: Design a symmetric protein trimer, with 3 identical chains of 80 residues each! This puzzle includes a Secondary Structure Objective, so no more than 50% of your design can form helices. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Categories: Design, Overall, Symmetry

Top Groups

RankGroupScorePoints
16BOINC@Poland01

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
16spdenne 43 64 Void Crushers19,82642
17robgee 7 9 Anthropic Dreams19,56639
18fiendish_ghoul 69 13  19,50537
19johnmitch 69 32  19,49935
20phi16 13 22 Anthropic Dreams19,48933


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Comments

bkoep's picture
User offline. Last seen 7 hours 50 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -150 points per atom (not including symmetric copies).

Core Existence: Monomer (max +1600)
Ensures that at least 22 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +1800)
Rewards networks that comprise at least 2 H-bonds involving core residues.
Between 1 and 9 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

spvincent's picture
User offline. Last seen 5 hours 6 min ago. Offline
Joined: 12/07/2007
Groups: Contenders
Now there's a new version of

Now there's a new version of Rosetta, perhaps you could allow insertion/deletion of residues again in this type of puzzle.

bkoep's picture
User offline. Last seen 7 hours 50 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Not yet!

The Foldit code will still require some modification before we can allow residue insertions/deletions in symmetry puzzles.

But we appreciate the continued feedback! We read you loud and clear that this is an important feature to add.

grogar7's picture
User offline. Last seen 9 hours 45 min ago. Offline
Joined: 10/03/2011
No crashes

Thanks to the team for recent efforts in improving the code! I have not experienced any crashes on this puzzle, even with the notorious Remix scripts :-)

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons