puzzle picture
2021: Symmetric Trimer Design: H-bond Networks
Status: Closed

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RankGroupScorePoints
1Contenders22,224100
2Anthropic Dreams21,91271
3Go Science21,85749
4Gargleblasters21,69733
5Marvin's bunch21,08722
6Beta Folders19,99314
7Void Crushers19,8268
8L'Alliance Francophone19,4455
9Australia18,1083
10SETI.Germany12,7262
11Team China12,4021
12METU-BIN 12,3961
13Czech National Team12,2841
14E?????! Heureka!10,9561
15Richard Dawkins Foundation01
16BOINC@Poland01


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bkoep's picture
User offline. Last seen 9 hours 56 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -150 points per atom (not including symmetric copies).

Core Existence: Monomer (max +1600)
Ensures that at least 22 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +1800)
Rewards networks that comprise at least 2 H-bonds involving core residues.
Between 1 and 9 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

spvincent's picture
User offline. Last seen 7 hours 54 min ago. Offline
Joined: 12/07/2007
Groups: Contenders
Now there's a new version of

Now there's a new version of Rosetta, perhaps you could allow insertion/deletion of residues again in this type of puzzle.

bkoep's picture
User offline. Last seen 9 hours 56 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Not yet!

The Foldit code will still require some modification before we can allow residue insertions/deletions in symmetry puzzles.

But we appreciate the continued feedback! We read you loud and clear that this is an important feature to add.

grogar7's picture
User offline. Last seen 11 hours 43 min ago. Offline
Joined: 10/03/2011
No crashes

Thanks to the team for recent efforts in improving the code! I have not experienced any crashes on this puzzle, even with the notorious Remix scripts :-)

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons