puzzle picture
2017: IL-2R Binder Design: Round 2
Status: Closed

Summary

Name: 2017: IL-2R Binder Design: Round 2
Status: Closed
Created: 07/09/2021
Points: 100
Expired: 07/16/2021 - 23:00
Difficulty: Intermediate
Description: Design a protein that can bind to the IL-2 receptor (IL-2R)! IL-2 is a signaling protein that helps to regulate the human immune system. When it binds to the IL-2 receptor on the surface of an immune cell, it can induce the immune cell to change its behavior or differentiate into a new cell type. The precise effects of IL-2 vary widely for different cells, depending on the cell type, the local environment, and even the concentration of IL-2. A synthetic form of IL-2 is approved in the U.S. to treat certain types of cancer, but is associated with severe side effects. We'd like to design a protein binder that can block binding at the IL-2 receptor and attenuate IL-2 signaling.

In this puzzle, we've presented a section of the target receptor that normally binds IL-2. The backbone and most of the sidechains are frozen, except at the binding site, where flexible sidechains are shown in color. Players can design a new protein that can bind to these sidechains and block IL-2. In order to bind the target receptor, designs will need to make lots of hydrophobic contacts and satisfy any polar atoms that are buried at the interface. But designs will also need to have lots of secondary structure (helices or sheets) and a large core, so that they fold up correctly! See the puzzle comments for Objective details.
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Contenders13,934100
2Anthropic Dreams13,87065
3Go Science13,60841
4Gargleblasters13,27624
5Beta Folders13,25314

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
1Galaxie 4 4 Anthropic Dreams13,866100
2dcrwheeler 70 6  13,78195
3BootsMcGraw 16 10 Contenders13,69390
4Bruno Kestemont 3 1 Go Science13,60884
5sallallami 70 17  13,57780


Need this puzzle? Log in to download.  

Comments

alcor29's picture
User is online Online
Joined: 11/16/2012
Comments missing

Comments missing. No SS limitations I'm presuming.

User login
Download links:
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.12 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media


Search
Only search fold.it
Other Games: Mozak
Recommend Foldit
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons