puzzle picture
Design of the Month: July 2021
Status: Closed

Summary

Name: Design of the Month: July 2021
Status: Closed
Created: 06/30/2021
Points: 0
Expired: 07/31/2021 - 23:00
Difficulty: Intermediate
Description: This sandbox puzzle features a D2 symmetric design, created by an anonymous player in Puzzle 1998. The monomer subunit takes on an unusual fold that has two beta-sheets, each of which creates a distinct interface with other symmetric subunits! The monomer subunit has a lot of hydrophobic surface area, which may spell trouble for proper folding; but if it does fold and assemble correctly, we would expect extremely tight binding between subunits. For more, check out Foldit Lab Report #22 on YouTube! This sandbox puzzle is non-competitive and will not award any points.

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Comments

mwm64's picture
User offline. Last seen 2 weeks 6 days ago. Offline
Joined: 05/21/2020
Groups: Gargleblasters
I'm pretty sure that was mine...

I just now filled out the form so you can mention me :-)

The idea was that that you can make a pattern of hydrophobics and polars on the outside of one sheet, and make a matching one (mirrored, rotated 90 degrees, and reversing polarities) on the other sheet so they match up. It turned out to not be quite that easy (the grids aren't quite square, etc.) but that was the idea.

Bautho's picture
User offline. Last seen 1 day 14 hours ago. Offline
Joined: 02/16/2012
Groups: Go Science
I'm pretty sure you are wrong ;)

just saying...

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons