puzzle picture
2011: Cortisol Ligand Binder Design
Status: Closed

Summary

Name: 2011: Cortisol Ligand Binder Design
Status: Closed
Created: 06/25/2021
Points: 100
Expired: 07/02/2021 - 23:00
Difficulty: Intermediate
Description: Design a binding pocket for the cortisol ligand! Cortisol is a natural signaling molecule that the body uses to regulate metabolism and inflammation. Commonly known as a "stress hormone," cortisol levels tend to increase under conditions of chronic stress. We'd like to design a cortisol binder that could be used to detect the hormone or sequester it from the blood stream. Cortisol is mostly hydrophobic, but has several polar atoms that need to be satisfied by H-bonds in the binding pocket!

In this puzzle, players are challenged to design a binding pocket for cortisol. We've provided a generic NTF2-type backbone as the starting structure, with the cortisol ligand placed roughly in the correct position in the binding pocket. However, players may completely redesign the protein or reposition the ligand within the binding pocket. Try to design a binding pocket with high Contact Surface and zero BUNS! See the puzzle comments for Objective details.
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Contenders15,178100
2Anthropic Dreams15,11263
3Go Science15,00737
4Marvin's bunch14,97021
5Void Crushers14,83511

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
1grogar7 40 1 Anthropic Dreams15,083100
2phi16 12 24 Anthropic Dreams15,00295
3mirp 9 10 Go Science15,00091
4WBarme1234 71 39  14,96186
5jausmh 14 36 Marvin's bunch14,94382


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Comments

bkoep's picture
User offline. Last seen 3 hours 8 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Contact Surface Metric (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 200 or more.

Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.

frood66's picture
User offline. Last seen 12 hours 12 min ago. Offline
Joined: 09/20/2011
Groups: Marvin's bunch
I have to submit this

why is this puzzle so much slower than others? yet it has less filters. Weird.

just saying

Dudit's picture
User offline. Last seen 40 min 37 sec ago. Offline
Joined: 12/26/2016
Groups: Go Science
122 amino acids / residues

This puzzle has a total of 122 amino acids / residues
That's why it's much slower than others

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons