Many Foldit players over the years have tried out protein design principles that originated in work done by Koga & Koga at the Baker lab at University of Washington (which is where Foldit was hatched). Now Koga & Koga have new paper out, exploring design principles for larger proteins, and proteins with functional sites.

The paper: https://www.nature.com/articles/s41467-021-24050-7

A nice summary for the layperson: https://www.eurekalert.org/pub_releases/2021-06/nion-rsa062321.php

Foldit Wiki page about the original Koga & Koga paper: https://foldit.fandom.com/wiki/Koga_%26_Koga