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2002: TGF Receptor Binder Design: Round 5
Status: Closed
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Soloists
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| 1 | Bruno Kestemont 3 2 | Go Science | 10,685 | 100 | | 2 | Bletchley Park 8 8 | Contenders | 10,663 | 96 | | 3 | grogar7 46 19 | Anthropic Dreams | 10,650 | 92 | | 4 | toshiue 46 863 | Go Science | 10,553 | 87 | | 5 | LociOiling 2 1 | Beta Folders | 10,448 | 83 | | 6 | sgeldhof 46 37 | | 10,400 | 80 | | 7 | frood66 32 32 | Marvin's bunch | 10,380 | 76 | | 8 | georg137 18 35 | Contenders | 10,323 | 72 | | 9 | mirp 46 1458 | Go Science | 10,251 | 69 | | 10 | Crossed Sticks 46 72 | | 10,249 | 65 | | 11 | Galaxie 1 3 | Anthropic Dreams | 10,151 | 62 | | 12 | silent gene 24 66 | Go Science | 10,146 | 59 | | 13 | johnmitch 46 1458 | | 9,918 | 56 | | 14 | Nicm25 46 454 | | 9,911 | 53 | | 15 | ucad 46 45 | | 9,877 | 51 | | 16 | dcrwheeler 46 4 | | 9,875 | 48 | | 17 | martinzblavy 46 1458 | Contenders | 9,868 | 46 | | 18 | spvincent 29 12 | Contenders | 9,831 | 43 | | 19 | BootsMcGraw 10 7 | Contenders | 9,784 | 41 | | 20 | Mike Cassidy 46 60 | Void Crushers | 9,778 | 39 | | 21 | robgee 7 6 | Anthropic Dreams | 9,766 | 37 | | 22 | phi16 9 29 | Anthropic Dreams | 9,751 | 35 | | 23 | fiendish_ghoul 46 34 | | 9,708 | 33 | | 24 | ShadowTactics 46 291 | BOINC@Poland | 9,640 | 31 | | 25 | zippyc137 46 16 | | 9,560 | 29 | Need this puzzle? Log in to download.
Comments
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DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.
Contact Surface (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.
Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.
Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets and helices.