puzzle picture
2002: TGF Receptor Binder Design: Round 5
Status: Closed

Groups

RankGroupScorePoints
1Anthropic Dreams10,707100
2Go Science10,68571
3Contenders10,66349
4Beta Folders10,44833
5Marvin's bunch10,42422
6Void Crushers9,77814
7BOINC@Poland9,6408
8Gargleblasters9,4725
9L'Alliance Francophone8,0853
10SETI.Germany7,2122
11Italiani Al Lavoro7,0551
12METU-BIN 6,7371
13Australia6,6471
14Team China5,0491
15NU Molecular Folding and Function 3,4911
16Foldit Staff01


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bkoep's picture
User offline. Last seen 9 hours 31 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.

Contact Surface (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.

Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.

Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets and helices.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons