puzzle picture
1998: Symmetric D2 Tetramer Design: Limited Interface
Status: Closed


1Go Science28,782100
2Anthropic Dreams28,38165
3Beta Folders27,88141
4Marvin's bunch27,68924
7Void Crushers25,8564
9L'Alliance Francophone24,2241
10Team China23,6101
12Italiani Al Lavoro14,4521

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bkoep's picture
User offline. Last seen 2 hours 4 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -200 points per atom (not including symmetric copies).

Core Existence: Monomer (max +2200)
Ensures that at least 22 residues are buried in the core of the monomer unit.

Core Limit: Complex (max +500)
Checks that no more than 116 residues are buried in the symmetric complex, including the interface between monomer units.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Joined: 09/24/2012
Groups: Go Science

It's easy to get independent monomers with 0 Buns. The bonus system doesnt encourage a polymer complex.

Bautho's picture
User offline. Last seen 5 days 7 hours ago. Offline
Joined: 02/16/2012
Groups: Go Science
green residues inside the monomer

I can compensate the (probably too many) orange residues at the interfaces by having more green residues inside the monomer's core (instead of orange ones), which gives me full bonus.
Is this intended?

Joined: 12/06/2008
Groups: Contenders
No H-bonds? What's the point?

If there is no bonus for making H-bonds, then how do we know we have the monomers correctly making a complex? Is there some other metric that indicates we have what the scientists want?

I ask this, because all arrangements of the monomers that are close to each other that I have tried result in drastic score reductions, even when BUNS and clashes are removed. What's the point of bringing monomers together, if doing so doesn't result in improvement?

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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