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1997: TGF Receptor Binder Design: Round 4
Status: Closed
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Soloists
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| 1 | Galaxie 1 3 | Anthropic Dreams | 10,935 | 100 | | 2 | mirp 46 1458 | Go Science | 10,614 | 96 | | 3 | Bletchley Park 8 8 | Contenders | 10,566 | 91 | | 4 | johnmitch 46 1458 | | 10,534 | 87 | | 5 | Crossed Sticks 46 72 | | 10,477 | 82 | | 6 | silent gene 24 66 | Go Science | 10,438 | 78 | | 7 | Bruno Kestemont 3 2 | Go Science | 10,406 | 74 | | 8 | robgee 7 6 | Anthropic Dreams | 10,346 | 70 | | 9 | sgeldhof 46 37 | | 10,325 | 67 | | 10 | martinzblavy 46 1458 | Contenders | 10,266 | 63 | | 11 | LociOiling 2 1 | Beta Folders | 10,068 | 60 | | 12 | ucad 46 45 | | 10,054 | 57 | | 13 | toshiue 46 863 | Go Science | 10,046 | 54 | | 14 | frood66 32 32 | Marvin's bunch | 10,012 | 51 | | 15 | OWM3 46 1458 | Gargleblasters | 10,007 | 48 | | 16 | Pazithi 46 62 | Gargleblasters | 9,978 | 45 | | 17 | dcrwheeler 46 4 | | 9,966 | 43 | | 18 | BootsMcGraw 10 7 | Contenders | 9,745 | 40 | | 19 | nspc 31 38 | Go Science | 9,667 | 38 | | 20 | akaaka 46 18 | | 9,621 | 36 | | 21 | drumpeter18yrs9yrs 46 107 | | 9,562 | 34 | | 22 | Vinara 46 57 | | 9,419 | 32 | | 23 | georg137 18 35 | Contenders | 9,381 | 30 | | 24 | NeLikomSheet 46 31 | | 9,365 | 28 | | 25 | alcor29 5 9 | Anthropic Dreams | 9,299 | 26 | Need this puzzle? Log in to download.
Comments
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DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.
Contact Surface (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.
Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.
Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets and helices.