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1997: TGF Receptor Binder Design: Round 4
Status: Closed
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Evolvers
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| 1 | Galaxie 1 3 | Anthropic Dreams | 10,989 | 100 | | 2 | alcor29 5 9 | Anthropic Dreams | 10,896 | 96 | | 3 | robgee 7 6 | Anthropic Dreams | 10,893 | 91 | | 4 | toshiue 46 863 | Go Science | 10,668 | 87 | | 5 | Bruno Kestemont 3 2 | Go Science | 10,569 | 82 | | 6 | mirp 46 1458 | Go Science | 10,555 | 78 | | 7 | silent gene 24 66 | Go Science | 10,538 | 74 | | 8 | Maerlyn138 46 1458 | Go Science | 10,477 | 70 | | 9 | mbinfield 46 1458 | Go Science | 10,434 | 67 | | 10 | georg137 18 35 | Contenders | 10,284 | 63 | | 11 | BootsMcGraw 10 7 | Contenders | 10,141 | 60 | | 12 | jausmh 17 30 | Marvin's bunch | 10,096 | 57 | | 13 | Bletchley Park 8 8 | Contenders | 10,084 | 54 | | 14 | LociOiling 2 1 | Beta Folders | 10,067 | 51 | | 15 | fpc 12 39 | Marvin's bunch | 9,985 | 48 | | 16 | ichwilldiesennamen 22 10 | Go Science | 9,644 | 45 | | 17 | Keresto 42 416 | Gargleblasters | 9,539 | 43 | | 18 | HMK 46 1458 | Gargleblasters | 8,381 | 40 | Need this puzzle? Log in to download.
Comments
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DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.
Contact Surface (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.
Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.
Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets and helices.